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World's smallest biomechanical linkage

Date:
August 23, 2021
Source:
Princeton University, Engineering School
Summary:
Researchers have built the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids called peptides.
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Researchers at Princeton University have built the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids called peptides.

In a paper published August 23 in Nature Chemistry, the team detailed a library of such structures made in their lab -- two interlocked rings, a ring on a dumbbell, a daisy chain and an interlocked double lasso -- each around one billionth of a meter in size. The study also demonstrates that some of these structures can toggle between at least two shapes, laying the groundwork for a biomolecular switch.

"We've been able to build a bunch of structures that no one's been able to build before," said A. James Link, professor of chemical and biological engineering, the study's principal investigator. "These are the smallest threaded or interlocking structures you can make out of peptides."

To craft these gadgets, dubbed mechanically interlocked peptides, or MIPs, the researchers used genetic engineering to manipulate individual amino acids in a naturally occurring lasso peptide, microcin J25, and direct the peptide to self-assemble into new shapes.

They also bypassed the need for the harsh solvents and metal ions used in building similar synthetic molecular architectures, work that was the focus of the 2016 Nobel Prize in chemistry. This work, using a single-pot protocol in water, leverages minimal control over the peptides' own form-finding program to create an entirely new class of technology.

"It's really building a bridge between the biological world," Link said, "and what until now has been the playground of synthetic chemistry."

In technical terms, the study shows microcin J25 lasso peptides converted into a [2]catenane, a rotaxane, a [c2]daisy chain and a double-lasso macrocycle. 


Story Source:

Materials provided by Princeton University, Engineering School. Original written by Scott Lyon. Note: Content may be edited for style and length.


Journal Reference:

  1. Hendrik V. Schröder, Yi Zhang, A. James Link. Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nature Chemistry, 2021; DOI: 10.1038/s41557-021-00770-7

Cite This Page:

Princeton University, Engineering School. "World's smallest biomechanical linkage." ScienceDaily. ScienceDaily, 23 August 2021. <www.sciencedaily.com/releases/2021/08/210823125818.htm>.
Princeton University, Engineering School. (2021, August 23). World's smallest biomechanical linkage. ScienceDaily. Retrieved October 31, 2024 from www.sciencedaily.com/releases/2021/08/210823125818.htm
Princeton University, Engineering School. "World's smallest biomechanical linkage." ScienceDaily. www.sciencedaily.com/releases/2021/08/210823125818.htm (accessed October 31, 2024).

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